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Notable People From McDonough County
- Elizabeth Magie, inventor of The Landlord's Game, precursor to Monopoly
- Peter Newell – Illustrator; Harper’s Bazaar, Alice’s Adventures In Wonderland
- Red Miller – Denver Broncos Head Coach
- Al Sears – Jazz Musician and early progenitor of Rock & Roll
- C.T. Vivian – Civil Rights leader
- Todd Purdum – Editor Vanity Fair, New York Times correspondent
- Phil Bradley – Major League Baseball Player
- Joe Garner – six-time New York Times best selling author
- Marcus Dunstan – Screenwriter – Saw sequels
- Charles Clarke Chapmen - first mayor of Fullerton, California; founder of Chapman University
- Charles Kuhn -cartoonist, comic strip writer born in Prairie City, IL.
Notable Western Illinois University Alumni
- Mary Matalin – Political consultant; Ronald Regan, George H.W. Bush, George W. Bush, Dick Cheney
- John Mahoney – actor – Steppenwolf Theatre, Frasier
- Michael Boatman – actor – Spin City
- Mark Konkol – Pulitzer Prize winning journalist (Chicago Sun-Times)
- Lee Calhoun – Olympic Gold Medalist
- Bryan Cox – NFL player and coach
- Rick & Paul Reuschel - MLB players